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One of the aims of the UKRMP in overcoming the barriers to regenerative medicine being used in mainstream therapies is the development of new tools reagents, protocols. Further details of the activities and progress across the Hubs and Platform can be found through the following reports, papers and documents

2018

Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes

Comenge J, Sharkey J, Fragueiro O, Wilm B, Mathias Brust M, Murray P, Levy R, Plagge A.
Accepted eLife Jun 2018
doi: https://doi.org/10.1101/199836
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering

B. Lucendo-Villarin, a H. Rashidi, a K. Camerona and D. C. Hay
J. Mater. Chem. 2016; B 4(20): 3433-3442.
doi:10.1039/c6tb00331a
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.

Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, Hanley NA, Hay DC, Ingelman-Sundberg M, Juhila S, Kitteringham N, Silva-Lima B, Norris A, Pridgeon C, Ross JA, Young RS, Tagle D, Tornesi B, van de Water B, Weaver RJ, Zhang F, Park BK.
Hepatology. 2017 Feb; 65(2): 710-721.
doi: 10.1002/hep.28886.
Epub 2016 Nov 30.
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis

Medina-Rodríguez EM, Bribián A,, Boyd A, Palomo V, Pastor J, Lagares A, Gil C, Martínez A, Williams A, de Castro F,.
Sci Rep. 2017 Mar 3;7:43545.
doi: 10.1038/srep43545.
Engineering and exploiting the stem cell niche (UKRMP1)
,
Multiple sclerosis

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury.

Lara Campana, Philip J. Starkey Lewis, Antonella Pellicoro, Rebecca L. Aucott, Janet Man, Eoghan O’Duibhir, Sarah E. Mok, Sofia Ferreira-Gonzalez, Eilidh Livingstone, Stephen N. Greenhalgh, Katherine L. Hull, Timothy J. Kendall, Douglas Vernimmen, Neil C. Henderson, Luke Boulter, Christopher D. Gregory, Yi Feng, Stephen M. Anderton, Stuart J. Forbes and John P. Iredale
J. Immunol. 2017.
doi:10.4049/jimmunol.1701247.
Epub 2017 Dec 20.
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

Extracellular Matrix Molecule-Based Capture of Mesenchymal Stromal Cells Under Flow

Massam-Wu T, Cain SA, Kielty CM.
Methods Mol Biol. 2018; 1722: 249-560.
doi:10.1007/978-1-4939-7553-2_16.
Engineering and exploiting the stem cell niche (UKRMP1)

Immunomodulatory role of keratin 76 in oral and gastric cancer.

Sequeira I, Carrero D, Peng Q, Palasz N, Liakath-Ali K, Lord G, Morgan P, Lombardi G, Watt FM.
BioRxiv https://doiorg/101101/305961. 2018.
Immunomodulation (UKRMP1)

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations.

Philippeos C, Telerman SB, Oulès B, Pisco AO, Shaw TJ, Elgueta R, Lombardi G, Driskell RR, Soldin M, Lynch MD, Watt FM.
J Invest Dermatol. 2018;138(4):811-25.
PMCID: PMC5869055
DOI: 10.1016/j.jid.2018.01.016
Immunomodulation (UKRMP1)

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

Ferreira-Gonzalez S, Lu WY, Raven A, Dwyer B, Man TY, O'Duibhir E, Lewis PJS, Campana L, Kendall TJ, Bird TG,,, Tarrats N, Acosta JC, Boulter L, Forbes SJ.
Nat Commun. 2018 Mar 9;9(1):1020.
doi: 10.1038/s41467-018-03299-5.
Engineering and exploiting the stem cell niche (UKRMP1)

Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications

Ong J, Serra MP, Segal J, Cujba AM, Ng SS, Butler R, Millar V, Hatch S, Zimri S, Koike H, Chan K, Bonham A, Walk M, Voss T, Heaton N, Mitry R, Dhawan A, Ebner D, Danovi D, Nakauchi H, Rashid ST.
Stem Cell Reports. 2018 Mar 13;10(3):693-702.
doi: 10.1016/j.stemcr.2018.01.025.
Epub 2018 Mar 1.
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy.

Fuhrmann G, Chandrawati R, Parmar PA, Keane TJ, Maynard SA, Bertazzo S, Stevens MM.
Adv Mater. 2018 Feb 23. doi: 10.1002/adma.201706616. [Epub ahead of print]
PMID: 2947323
Acellular (UKRMP1)

Liposomal Delivery of Demineralized Dentin Matrix for Dental Tissue Regeneration.

Melling GE, Colombo JS, Avery SJ, Ayre WN, Evans SL, Waddington RJ, Sloan AJ.
Tissue Eng Part A. 2018 Feb 21. doi: 10.1089/ten.TEA.2017.0419. [Epub ahead of print]
PMID: 29316874
Acellular (UKRMP1)

A biomaterials approach to influence stem cell fate in injectable cell-based therapies.

Amer MH, Rose FRAJ, Shakesheff KM, White LJ.
Stem Cell Res Ther. 2018 Feb 21;9(1):39. doi: 10.1186/s13287-018-0789-1.
PMID: 2946701
Acellular (UKRMP1)

Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors

Bantounas I, Ranjzad P, Tengku F, Silajdzic E, Forster D, Asselin M, Lewis P, Lennon R, Plagge A, Wang Q, Woolf AS, and Kimber SJ
Stem Cell Reports. 2018 Mar 13;10(3):766-779.
doi: 10.1016/j.stemcr.2018.01.008.
Epub 2018 Feb 8.
Kidney
,
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair.

Keane TJ, Horejs CM, Stevens MM.
Adv Drug Deliv Rev. 2018 Feb 6. pii: S0169-409X(18)30030-9.
doi: 10.1016/j.addr.2018.02.002. [Epub ahead of print]
PMID: 29425770
Acellular (UKRMP1)

Biomaterials for Regenerative Medicine Approaches for the Anterior Segment of the Eye.

Williams R, Lace R, Kennedy S, Doherty K, Levis H.
Adv Healthc Mater. 2018 Feb 1. doi: 10.1002/adhm.201701328. [Epub ahead of print] Review.
PMID: 29388397
Acellular (UKRMP1)
,
Eye

Collectin-11 Promotes the Development of Renal Tubulointerstitial Fibrosis.

Wu W, Liu C, Farrar CA, Ma L, Dong X, Sacks SH, Li K, Zhou W.
J Am Soc Nephrol. 2018;29(1):168-81.
PMCID: PMC5748920 [Available on 2019-01-01]
DOI:10.1681/ASN.2017050544
Immunomodulation (UKRMP1)

Post-Modified Polypeptides with UCST-Type Behavior for Control of Cell Attachment in Physiological Conditions.

Xue X, Thiagarajan L, Dixon JE, Saunders BR, Shakesheff KM, Alexander C.
Materials (Basel). 2018 Jan 9;11(1). pii: E95. doi: 10.3390/ma11010095.
PMID: 29315257
Acellular (UKRMP1)

Clay nanoparticles for regenerative medicine and biomaterial design: A review of clay bioactivity.

Mousa M, Evans ND, Oreffo ROC, Dawson JI.
Biomaterials. 2018 Mar;159:204-214. doi: 10.1016/j.biomaterials.2017.12.024. Epub 2018 Jan 3. Review.
PMID: 29331807
Acellular (UKRMP1)

2017

Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis

Mads S. Bergholt, Andrea Serio, James S. McKenzie,#Amanda Boyd,¶Renata F. Soares, Jocelyn Tillner, Ciro Chiappini, Vincen Wu,Andreas Dannhorn, Zoltan Takats, Anna Williams and Molly M. Stevens
ACS Central Science 2017.
doi: 10.1021/acscentsci.7b00367.
[Epub ahead of print]
Engineering and exploiting the stem cell niche (UKRMP1)
,
Multiple sclerosis

Recombinant Extracellular Matrix Protein fragments Support Human Embryonic Stem Cell Chondrogenesis

Cheng A, Cain SA, Tian P, Baldwin AK, Uppanan P, Kielty CM, Kimber SJ.
Tissue Eng Part A.
doi: 10.1089/ten.TEA.2017.0285.
Epub 2017 Dec 27.
Engineering and exploiting the stem cell niche (UKRMP1)

Assessing the Effectiveness of a Far-red Fluorescent Reporter for Tracking Stem Cells In Vivo

Zhou J, Sharkey J, Shukla R, Plagge A and Murray P
Int J Mol Sci. 2017 Dec 22;19(1). pii: E19.
doi: 10.3390/ijms19010019.
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety.

Meseguer-Ripolles J, Khetani SR, Blanco JG, Iredale M, Hay DC.
AAPS J. 2017: 20(1), 20.
doi: 10.1208/s12248-017-0171-8.
Epub 2017 Dec 21.
Engineering and exploiting the stem cell niche (UKRMP1)

SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?

Barrow M, Taylor A, Fuentes-Caparrós AM, Sharkey J, Daniels LM, Mandal P, Park BK, Murray P, Rosseinsky MJ, Adams DJ.
Biomater Sci. 2017 Dec 19;6(1):101-106.
doi: 10.1039/c7bm00515f.
Smart Materials

Roadmap to clinical translation: insights from a UK regenerative medicine platform workshop on mesenchymal stromal cells.

Asante CO and Dazzi F.
Regen Med. 2017 Dec;12(8), 895–897
Cardiovascular
,
Eye
,
Kidney
,
Musculoskeletal

Roadmap to clinical translation: insights from a UK regenerative medicine platform workshop on mesenchymal stromal cells.

Asante CO, Dazzi F.
PMID: 29243943
DOI:10.2217/rme-2017-0097
Immunomodulation (UKRMP1)

Roadmap to clinical translation: insights from a UK regenerative medicine platform workshop on mesenchymal stromal cells.

Asante CO, Dazzi F.
Regen Med. 2017 Dec 15.
doi: 10.2217/rme-2017-0097.
Immunomodulation (UKRMP1)

Osteogenic Programming of Human Mesenchymal Stem Cells with Highly Efficient Intracellular Delivery of RUNX2.

Thiagarajan L, Abu-Awwad HAM, Dixon JE.
Stem Cells Transl Med. 2017 Dec;6(12):2146-2159. doi: 10.1002/sctm.17-0137. Epub 2017 Oct 31.
PMID:29090533
Acellular (UKRMP1)

Liver cell therapy: is this the end of the beginning?

Alwahsh SM, Rashidi H, Hay DC.
Cell Mol Life Sci. 2017 Nov 27.
doi: 10.1007/s00018-017-2713-8.
[Epub ahead of print]
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver
,
Skin

Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress.

Fanelli G, Gonzalez-Cordero A, Gardner PJ, Peng Q, Fernando M, Kloc M, Farrar CA, Naeem A, Garred P, Ali RR, Sacks SH.
Sci Rep. 2017;7(1):14625.
PMCID: PMC5677091
DOI: 10.1038/s41598-017-15212-z
Immunomodulation (UKRMP1)

Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy

Gillies D et al.
Methods. 2018 Mar 1;136:126-133.
doi: 10.1016/j.ymeth.2017.10.010.
Epub 2017 Oct 31.
Engineering and exploiting the stem cell niche (UKRMP1)

Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow-derived human mesenchymal stem cells for bone tissue regeneration

Reinwald Y, El Haj AJ.
J Biomed Mater Res A. 2017 Oct 6.
doi: 10.1002/jbm.a.36267.
[Epub ahead of print]
Engineering and exploiting the stem cell niche (UKRMP1)

The Chorioallantoic Membrane Assay for Biomaterial Testing in Tissue Engineering: A Short-Term In Vivo Preclinical Model.

Moreno-Jiménez I, Kanczler JM, Hulsart-Billstrom G, Inglis S, Oreffo ROC.
Tissue Eng Part C Methods. 2017 Dec;23(12):938-952.
doi: 10.1089/ten.TEC.2017.0186. Epub 2017 Oct 20.
PMID:28877648
Acellular (UKRMP1)

Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies

Scarfe L, Brillant N, Dinesh Kumar J, Ali N, Alrumayh A, Amali M, Barbellion S, Jones V, Niemeijer M, Potdevin S, Roussignol G, Vaganov A, Barbaric I, Barrow M, Burton NC, Connell J, Dazzi F, Edsbagge J, French NS, Holder J, Hutchinson C, Jones DR, Kalber T, Lovatt C, Lythgoe MF, Patel S, Patrick PS, Piner J, Reinhardt J, Ricci E, Sidaway J, Stacey GN, Starkey Lewis PJ, Sullivan G, Taylor A, Wilm B, Poptani H, Murray P, Goldring CEP, Park BK
NPJ Regen Med. 2017 Oct 19;2:28.
doi: 10.1038/s41536-017-0029-9.
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation.

Galleu A, Riffo-Vasquez Y, Trento C, Lomas C,, Dolcetti L, Cheung TS, von Bonin M, Barbieri L, Halai K, Ward S, Weng L, Chakraverty R,, Lombardi G, Watt FM, Orchard K, Marks DI, Apperley J, Bornhauser M, Walczak H, Bennett C, Dazzi F.
Sci Transl Med. 2017;9(416).
PMID: 29141887
DOI:10.1126/scitranslmed.aam7828
Immunomodulation (UKRMP1)

The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells.

Levato R, Webb WR, Otto IA, Mensinga A, Zhang Y, van Rijen M, van Weeren R, Khan IM, Malda J.
Acta Biomater. 2017 Oct 1;61:41-53. doi: 10.1016/j.actbio.2017.08.005. Epub 2017 Aug 4.
PMID: 28782725
Acellular (UKRMP1)

Remote regulation of magnetic particle targeted Wnt signaling for bone tissue engineering.

Rotherham M, Henstock JR, Qutachi O, El Haj AJ.
Nanomedicine. 2018 Jan;14(1):173-184.
doi: 10.1016/j.nano.2017.09.008.
Epub 2017 Sep 29.
PMID: 28965980
Acellular (UKRMP1)

Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies.

Scarfe L, Brillant N, Kumar JD, Ali N, Alrumayh A, Amali M, Barbellion S, Jones V, Niemeijer M, Potdevin S, Roussignol G, Vaganov A, Barbaric I, Barrow M, Burton NC, Connell J, Dazzi F, Edsbagge J, French NS, Holder J, Hutchinson C, Jones DR, Kalber T, Lovatt C, Lythgoe MF, Patel S, Patrick PS, Piner J, Reinhardt J, Ricci E, Sidaway J, Stacey GN, Starkey Lewis PJ, Sullivan G, Taylor A, Wilm B, Poptani H, Murray P, Goldring CEP, Park BK,.
NPJ Regen Med. 2017;2:28.
PMCID: PMC5677988
DOI: 10.1038/s41536-017-0029-9
Immunomodulation (UKRMP1)

Peptide hydrogels: A tissue engineering strategy for the prevention of oesophageal strictures.

Kumar D, Workman VL, O’Brien M, McLaren J, White L, Ragunath K, Rose F, Saiani A, Gough JE.
Advanced Functional Materials 2017 Aug 21.
DOI: 10.1002/adfm.201702424
Acellular (UKRMP1)

Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges.

Amer MH, Rose FRAJ, Shakesheff KM, Modo M, White LJ.
NPJ Regen Med. 2017 Aug 10;2:23. doi: 10.1038/s41536-017-0028-x. eCollection 2017. Review.
PMID: 29302358
Acellular (UKRMP1)

Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo.

Brillant N, Elmasry M, Burton NC, Rodriguez JM, Sharkey JW, Fenwick S, Poptani H, Kitteringham NR, Goldring CE, Kipar A, Park BK, Antoine DJ.
Toxicol Appl Pharmacol. 2017 Oct 1;332:64-74.
doi:10.1016/j.taap.2017.07.019.
Epub 2017 Jul 26.
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Wnt ligand presentation and reception: from the stem cell niche to tissue engineering

Kate M. Mills, James L. A. Szczerkowski, Shukry J. Habib
Open Biol. 2017: 7, 170140.
doi:10.1098/rsob.170140
Published online 21 July 2017
Engineering and exploiting the stem cell niche (UKRMP1)

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

Raven, A. et al.
Nature 2017 July; 547: 350-354.
doi:10.1038/nature23015.
Epub 2017 July 12.
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. ISCI Bar Harbour Meeting Report.

Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ, Stacey GN.
Stem Cell Reports Vol. 9 j 1–4 j July 11, 2017
Cell behaviour, differentiation and manufacturing (UKRMP1)

Extracellular vesicles are independent metabolic units with asparaginase activity.

Iraci N, Gaude E, Leonardi T, Costa ASH, Cossetti C, Peruzzotti-Jametti L, Bernstock JD, Saini HK, Gelati M, Vescovi AL, Bastos C, Faria N, Occhipinti LG, Enright AJ, Frezza C, Pluchino S.
Nat Chem Biol. 2017 Jul 3. doi: 10.1038/nchembio.2422. [Epub ahead of print]
PMID: 28671681
Acellular (UKRMP1)

Constructing cellular niche properties by localized presentation of Wnt proteins on synthetic surfaces

Molly Lowndes, Sergi Junyent & Shukry J Habib
Nature Protocols 2017: 12, 1498–1512.
doi:10.1038/nprot.2017.061
Published online 29 June 2017
Engineering and exploiting the stem cell niche (UKRMP1)

The adaptive immune response to cardiac injury—the true roadblock to effective regenerative therapies?

Susanne Sattler, Paul Fairchild, Fiona M. Watt, Nadia Rosenthal & Sian E. Harding
Regenerative Medicine. 2017; 2:19
doi:10.1038/s41536-017-0022-3
Cardiovascular

The adaptive immune response to cardiac injury-the true roadblock to effective regenerative therapies?

Sattler S, Fairchild P, Watt FM, Rosenthal N, Harding SE.
NPJ Regen Med. 2017;2:19.
PMCID: PMC5677967
DOI: 10.1038/s41536-017-0022-3
Cardiovascular
,
Immunomodulation (UKRMP1)

Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. ISCI Bar Harbour Meeting Report.

Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ, Stacey GN.
Stem Cell Reports Vol. 9 j 1–4 j July 11, 2017
Cell behaviour, differentiation and manufacturing (UKRMP1)

Platelet-rich plasma induces post-natal maturation of immature articular cartilage and correlates with LOXL1 activation.

Zhang Y, Morgan BJ, Smith R, Fellows CR, Thornton C, Snow M, Francis LW, Khan IM.
Sci Rep. 2017 Jun 16;7(1):3699. doi: 10.1038/s41598-017-02297-9.
PMID: 28623328
Acellular (UKRMP1)

A Modified Protocol for the Isolation of Primary Human Hepatocytes with Improved Viability and Function from Normal and Diseased Human Liver.

Bartlett DC, Newsome PN.
Methods Mol Biol. 2017;1506:61-73.
PMID: 27830545
DOI: 10.1007/978-1-4939-6506-9_4
Immunomodulation (UKRMP1)
,
Liver

Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy

Bergholt MS, Albro MB, Stevens MM.
Biomaterials 2017; 140:128-137.
doi: 10.1016/j.biomaterials.2017.06.015.
Epub 2017 Jun 14.
Engineering and exploiting the stem cell niche (UKRMP1)

Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information.

Horejs CM, St-Pierre JP, Ojala JRM, Steele JAM, da Silva PB, Rynne-Vidal A, Maynard SA, Hansel CS, Rodríguez-Fernández C, Mazo MM, You AYF, Wang AJ, von Erlach T, Tryggvason K, López-Cabrera M, Stevens MM.
Nat Commun. 2017 Jun 8;8:15509.
doi: 10.1038/ncomms15509.
PMID: 28593951
Acellular (UKRMP1)

Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis

Mads S. Bergholt, Andrea Serio, James S. McKenzie,Amanda Boyd, Renata F. Soares,Jocelyn Tillner, Ciro Chiappini,Vincen Wu, Andreas Dannhorn, Zoltan Takats, Anna Williams and Molly M. Stevens
ACS Central Science 2017.
doi: 10.1021/acscentsci.7b00367.
[Epub ahead of print]
Engineering and exploiting the stem cell niche (UKRMP1)
,
Multiple sclerosis

Epigenetic resetting of human pluripotency.

Ge Guo, Ferdinand von Meyenn, Maria Rostovskaya, James Clarke, Sabine Dietmann, Duncan Baker, Anna Sahakyan, Samuel Myers, Paul Bertone, Wolf Reik, Kathrin Plath, Austin Smith
Development 144: 2748-2763
doi:10.1242/dev.146811.
Cell behaviour, differentiation and manufacturing (UKRMP1)

REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and ‐independent pathways

Janelle Drouin‐Ouellet, Shong Lau, Per Ludvik Brattås, Daniella Rylander Ottosson, Karolina Pircs, Daniela A Grassi, Lucy M Collins, Romina Vuono, Annika Andersson Sjöland, Gunilla Westergren‐Thorsson, Caroline Graff, Lennart Minthon, Håkan Toresson, Roger A Barker, Johan Jakobsson, Malin Parmar
EMBO Molecular Medicine, 9(8), 1117–1131
doi:10.15252/emmm.201607471

Regenerative Medicine: Advances from Developmental to Degenerative Diseases

Nicholas F. Blair, Thomas J. R. Frith, Ivana Barbaric
Advances in Experimental Medicine and Biology Book Series (AEMB, volume 1007): Personalised Medicine Chapter 12 pp 225-239
doi:10.1007/978-3-319-60733-7_12
Cell behaviour, differentiation and manufacturing (UKRMP1)

Raman spectroscopy and regenerative medicine: a review

Katherine J. I. Ember, Marieke A. Hoeve, Sarah L. McAughtrie, Mads S. Bergholt, Benjamin J. Dwyer, Molly M. Stevens, Karen Faulds, Stuart J. Forbes and Colin J. Campbell
npj Regenerative Medicine, 2017 May (12)
doi:10.1038/s41536-017-0014-3.
Epub 2017 May 15
Engineering and exploiting the stem cell niche (UKRMP1)

Controlled release of GAG-binding enhanced transduction (GET) peptides for sustained and highly efficient intracellular delivery.

Abu-Awwad HAM, Thiagarajan L, Dixon JE.
Acta Biomater. 2017 Jul 15;57:225-237. doi: 10.1016/j.actbio.2017.04.028. Epub 2017 Apr 27.
PMID: 28457961
Acellular (UKRMP1)

Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.

Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM, Lechler RI, Maher J, Smyth LA, Lombardi G.
Am J Transplant. 2017;17(4):931-43.
PMID: 28027623
DOI:10.1111/ajt.14185
Immunomodulation (UKRMP1)
,
Skin

Surface modification of PdlLGA microspheres with gelatine methacrylate: Evaluation of adsorption, entrapment, and oxygen plasma treatment approaches.

Baki A, Rahman CV, White LJ, Scurr DJ, Qutachi O, Shakesheff KM.
Acta Biomater. 2017 Apr 15;53:450-459.
doi: 10.1016/j.actbio.2017.01.042. Epub 2017 Jan 16.
PMID: 28093368
Acellular (UKRMP1)

MicroRNA-122 can be measured in capillary blood which facilitates point-of-care testing for drug-induced liver injury.

Vliegenthart ADB, Berends C, Potter CMJ, Kersaudy-Kerhoas M, Dear JW.
Br J Clin Pharmacol. 2017 Sep; 83 (9): 2027-2033.
doi: 10.1111/bcp.13282.
Epub 2017 Apr 5.
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

Neural grafting for Parkinson’s disease: challenges and prospects

Thomas B Stoker BA (Hons), MB BChir, Nicholas F Blair, Roger A Barker
Neural Regen Res;12:389-92
doi:10.4103/1673-5374.202935
Cell behaviour, differentiation and manufacturing (UKRMP1)
,
Parkinson’s disease

Human kidney-derived cells ameliorate acute kidney injury without engrafting into renal tissue.

Santeramo I, Herrera Perez Z, Illera A, Taylor A, Kenny S, Murray P, Wilm B, Gretz N.
Stem Cells Transl Med. 2017 May;6(5):1373-1384.
doi: 10.1002/sctm.16-0352.
Epub 2017 Apr 4.
Kidney
,
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Quantitative volumetric Raman imaging of three dimensional cell cultures

Kallepitis C, Bergholt MS, Mazo MM, Leonardo V, Skaalure SC, Maynard SA, Stevens MM
Nature Comms. 2017 March; 8:14843.
doi: 10.1038/ncomms14843.
Epub 2017 Mar 22.
Engineering and exploiting the stem cell niche (UKRMP1)

Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis

Medina-Rodríguez EM, Bribián A, Boyd A, Palomo V, Pastor J, Lagares A, Gil C, Martínez A, Williams A, de Castro F
Sci Rep. 2017 Mar 3;7:43545.
doi: 10.1038/srep43545.
Engineering and exploiting the stem cell niche (UKRMP1)
,
Multiple sclerosis

T cell immunoengineering with advanced biomaterials.

Delcassian D, Sattler S, Dunlop IE.
Integr Biol (Camb). 2017 Mar 1;9(3):211-222. doi: 10.1039/c6ib00233a. Epub 2017 Mar 2.
PMID: 28252135
Acellular (UKRMP1)

Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease.

Hasham MG, Baxan N, Stuckey DJ, Branca J, Perkins B, Dent O, Duffy T, Hameed TS, Stella SE, Bellahcene M, Schneider MD, Harding SE, Rosenthal N,, Sattler S.
Dis Model Mech. 2017;10(3):259-70.
PMCID: PMC5374321
DOI:10.1242/dmm.027409
Cardiovascular
,
Immunomodulation (UKRMP1)

Chapter 7: Strategies for bringing stem cell-derived dopamine neurons to the clinic

Agnete Kirkeby, Malin Parmar, Roger A.Barker
Progress in Brain Research, Volume 230, Issue null, Pages 165-190
doi.org/10.1016/bs.pbr.2016.11.011
Cell behaviour, differentiation and manufacturing (UKRMP1)

A novel drug induced hybrid electrospun PCL – cell derived ECM scaffold for liver tissue engineering

Grant Rhiannon, Hay David C. and Callanan Anthony
Tissue Engineering Part A. February 2017, ahead of print.
doi:10.1089/ten.TEA.2016.0419.
Engineering and exploiting the stem cell niche (UKRMP1)

Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence.

Fellows CR, Williams R, Davies IR, Gohil K, Baird DM, Fairclough J, Rooney P, Archer CW, Khan IM.
Sci Rep. 2017 Feb 2;7:41421.
doi: 10.1038/srep41421.
PMID: 28150695
Acellular (UKRMP1)

2016

Beneath the sword of Damocles: regenerative medicine and the shadow of immunogenicity.

Paul J Fairchild , Christopher Horton , Priyoshi Lahiri , Kumaran Shanmugarajah & Timothy J Davies
Regen Med. 2016 Dec;11(8):817-829.
doi:10.2217/rme-2016-0134

Beneath the sword of Damocles: regenerative medicine and the shadow of immunogenicity.

Fairchild PJ, Horton C, Lahiri P, Shanmugarajah K, Davies TJ.
Regen Med. 2016;11(8):817-29.
PMID: 27905261
DOI:10.2217/rme-2016-0134
Immunomodulation (UKRMP1)

Raman Spectroscopy Reveals New Insights into the Zonal Organization of Native and Tissue-Engineered Articular Cartilage

Mads S. Bergholt, Jean-Philippe St-Pierre, Giovanni S. Offeddu, Paresh A. Parmar, Michael B. Albro, Jennifer L. Puetzer, Michelle L. Oyen, and Molly M. Stevens
ACS Cent. Sci.; 2016
DOI: 10.1021/acscentsci.6b00222.
Epub Date: November 16, 2016
Engineering and exploiting the stem cell niche (UKRMP1)

A novel rodent model of severe renal ischemia reperfusion injury.

Whalen H, Shiels P, Littlejohn M, Clancy M.
Ren Fail. 2016 Nov;38(10):1694-1701.
doi:10.3109/0886022X.2016.1144024.
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Detecting Genetic Mosaicism in Cultures of Human Pluripotent Stem Cells.

Duncan Baker , Adam J. Hirst , Paul J. Gokhale , Miguel A. Juarez , Steve Williams , Mark Wheeler , Kerry Bean , Thomas F. Allison , Harry D. Moore , Peter W. Andrews , Ivana Barbaric
Stem Cell Reports, 7(5), 998-1012
Volume 7, Issue 5, p998–1012
Cell behaviour, differentiation and manufacturing (UKRMP1)

ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions

Stuart A. Cain, Ewa J. Mularczyk, Mukti Singh, Teresa Massam-Wu & Cay M. Kielty
Sci Rep (2016) 6, 35956.
Engineering and exploiting the stem cell niche (UKRMP1)

A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data

Kerz M, Folarin A, Meleckyte R, Watt FM, Dobson RJ, Danovi D.
J Biomol Screen 2016;
doi:10.1177/1087057116652064
Engineering and exploiting the stem cell niche (UKRMP1)

Engineered Microenvironments to Direct Epidermal Stem Cell Behavior at Single-Cell Resolution

Watt, F. M
Developmental Cell, 2016;38(6), 601-609
doi: http://dx.doi.org/10.1016/j.devcel.2016.08.010
Engineering and exploiting the stem cell niche (UKRMP1)

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer KH, Metzger M, Hotta R, Young HM, Andrews PW, Thapar N, Belkind-Gerson J, Bondurand N, Bornstein JC, Chan WY, Cheah K, Gershon MD, Heuckeroth RO, Hofstra RM, Just L, Kapur RP, King SK, McCann CJ, Nagy N, Ngan E, Obermayr F, Pachnis V, Pasricha PJ, Sham MH, Tam P, Vanden Berghe P.
Dev Biol. (2016)
doi:10.1016/j.ydbio.2016.04.001.
Cell behaviour, differentiation and manufacturing (UKRMP1)

Metabolic determinants of the immune modulatory function of neural stem cells.

Drago D, Basso V, Gaude E, Volpe G, Peruzzotti-Jametti L, Bachi A, Musco G, Andolfo A, Frezza C, Mondino A, Pluchino S.
J Neuroinflammation. 2016 Sep 2;13(1):232.
doi: 10.1186/s12974-016-0667-7.
PMID: 27590826
Acellular (UKRMP1)

The chorioallantoic membrane (CAM) assay as an ex vivo bioreactor of human bone regeneration: a replacement model for animal research.

Moreno-Jimenez I, Hulsart-Billstrom G, Lanham SA, Janeczek JA, Kontouli N, Kanczler JM, Evans ND and Oreffo ROC.
2016 Sci Rep. 2016 Aug 31;6:32168. doi: 10.1038/srep32168. PMID: 27577960
Acellular (UKRMP1)

Temporally degradable collagen-mimetic hydrogels tuned to chondrogenesis of human mesenchymal stem cells

Parmar PA, Skaalure SC, Chow LW, St-Pierre JP, Stoichevska V, Peng YY, Werkmeister JA, Ramshaw JA, Stevens MM.
Biomaterials 2016; 99: 56-71.
doi:10.1016/j.biomaterials.2016.05.011
Engineering and exploiting the stem cell niche (UKRMP1)

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis

Gieseck RL rd, Ramalingam TR, Hart KM, Vannella KM, Cantu DA, Lu WY, Ferreira-González S, Forbes SJ, Vallier L, Wynn TA.
Immunity 2016; 45(1): 145-158.
doi:10.1016/j.immuni.2016.06.009
Engineering and exploiting the stem cell niche (UKRMP1)

Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14–15 September 2015

David J Williams, Richard Archer, Peter Archibald, Ioannis Bantounas, Ricardo Baptista, Roger Barker, Jacqueline Barry, Florence Bietrix, Nicholas Blair, Julian Braybrook, Jonathan Campbell, Maurice Canham, Amit Chandra, Gabor Foldes, Rudy Gilmanshin, Mathilde Girard, Erwin Gorjup, Zöe Hewitt, Paul Hourd, Johan Hyllner, Helen Jesson, Jasmin Kee, Julie Kerby, Nina Kotsopoulou, Stanley Kowalski, Chris Leidel, Damian Marshall, Louis Masi, Mark McCall, Conor McCann, Nicholas Medcalf, Harry Moore, Hiroki Ozawa, David Pan, Malin Parmar, Anne L Plant, Yvonne Reinwald, Sujith Sebastian, Glyn Stacey, Robert J Thomas, Dave Thomas, Jamie Thurman- Newell, Marc Turner, Loriana Vitillo, Ivan Wall, Alison Wilson, Jacqueline Wolfrum, Ying Yang & Heiko Zimmerman
Regen Med. (2016),11 (5)
doi:10.2217/rme-2016-0053.
Epub 2016 Jul 12
Cell behaviour, differentiation and manufacturing (UKRMP1)

Comparability: manufacturing, characterisation and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2016

David J Williams, Richard Archer, Peter Archibald, Ioannis Bantounas, Ricardo Baptista, Roger Barker, Jacqueline Barry, Florence Bietrix, Nicholas Blair, Julian Braybrook, Jonathan Campbell, Maurice Canham, Amit Chandra, Gabor Foldes, Rudy Gilmanshin, Mathilde Girard, Erwin Gorjup, Zöe Hewitt, Paul Hourd, Johan Hyllner, Helen Jesson, Jasmin Kee, Julie Kerby, Nina Kotsopoulou, Stanley Kowalski, Chris Leidel, Damian Marshall, Louis Masi, Mark McCall, Conor McCann, Nicholas Medcalf, Harry Moore, Hiroki Ozawa, David Pan, Malin Parmar, Anne L Plant, Yvonne Reinwald, Sujith Sebastian, Glyn Stacey, Robert J Thomas, Dave Thomas, Jamie Thurman- Newell, Marc Turner, Loriana Vitillo, Ivan Wall, Alison Wilson, Jacqueline Wolfrum, Ying Yang & Heiko Zimmerman
Regen Med. (2016), 11 (5),
doi:10.2217/rme-2016-0053.
Epub 2016 Jul 12.
Cell behaviour, differentiation and manufacturing (UKRMP1)

Immobilized WNT Proteins Act as a Stem Cell Niche for Tissue Engineering

Lowndes M, Rotherham M, Price JC, El Haj AJ, Habib SJ.
Stem Cell Reports 2016; 7(1): 126-137.
doi:10.1016/j.stemcr.2016.06.004
Engineering and exploiting the stem cell niche (UKRMP1)

CIRM and UKRMP: Different Ways to Invest in Regenerative Medicine

Irving L.Weissman, Fiona M.Watt
Cell Stem Cell. 2016 Jul 7;19(1):19-22.
doi: 10.1016/j.stem.2016.05.011.

CIRM and UKRMP: Different Ways to Invest in Regenerative Medicine.

Weissman IL, Watt FM.
Cell Stem Cell. 2016;19(1):19-22.
PMID: 27392224
DOI: 10.1016/j.stem.2016.05.011
Immunomodulation (UKRMP1)

Harnessing the Versatility of Bacterial Collagen to Improve the Chondrogenic Potential of Porous Collagen Scaffolds

Parmar PA, St-Pierre JP, Chow LW, Puetzer JL, Stoichevska V, Peng YY, Werkmeister JA, Ramshaw JA, Stevens MM.
Adv Healthc Mater 2016; 5(13): 1656-1666.
doi:10.1002/adhm.201600136
Engineering and exploiting the stem cell niche (UKRMP1)

Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease.

Sharkey J, Scarfe L, Santeramo I, Garcia-Finana M, Park BK, Poptani H, Wilm B, Taylor A, Murray P.
Eur J Pharmacol. 2016 Jul 1. pii: S0014-2999(16)30426-5.
doi: 10.1016/j.ejphar.2016.06.056.
Kidney
,
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Co-precipitation of DEAE-dextran coated SPIONs: how synthesis conditions affect particle properties, stem cell labelling and MR contrast.

Barrow M, Taylor A, García Carrión J, Mandal P, Park BK, Poptani H, Murray P, Rosseinsky MJ, Adams DJ.
Contrast Media Mol Imaging. 2016 Sep;11(5):362-370.
doi: 10.1002/cmmi.1700.
Epub 2016 Jun 30.
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Making it personal: the prospects for autologous pluripotent stem cell derived therapies

Nicholas F Blair & Roger A Barker
Regenerative Medicine 2016
doi:10.2217/rme-2016-0057
Epub 2016 Jun 27.
Cell behaviour, differentiation and manufacturing (UKRMP1)

Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo.

Comenge J, Fragueiro O, Sharkey J, Taylor A, Held M, Burton NC, Park BK, Wilm B, Murray P, Brust M, Lévy R.
ACS Nano. 2016 Jul 26;10(7):7106-16.
doi: 10.1021/acsnano.6b03246.
Epub 2016 Jun 20.

Basement membrane fragments in the context of the epithelial-to-mesenchymal transition.

Horejs CM.
Eur J Cell Biol. 2016 Nov;95(11):427-440. doi: 10.1016/j.ejcb.2016.06.002. Epub 2016 Jun 18. Review.
PMID: 27397693
Acellular (UKRMP1)

Induced Pluripotent Stem Cell Therapies for Degenerative Disease of the Outer Retina: Disease Modeling and Cell Replacement.

Di Foggia V, Makwana P, Ali RR, Sowden JC.
J Ocul Pharmacol Ther. 2016;32(5):240-52.
PMCID: PMC4904163
DOI:10.1089/jop.2015.0143
Immunomodulation (UKRMP1)

Harnessing the versatility of bacterial collagen to improve the chondrogenic potential of porous collagen scaffolds.

P. A. Parmar, J. –P. St-Pierre, L. W. Chow, J. L. Puetzer, V. Stoichevska, Y. Y. Peng, J. A. Werkmeister, J. A. M. Ramshaw, M. M. Stevens.
Adv Healthc Mater. 2016 Jul;5(13):1656-66. doi: 10.1002/adhm.201600136. Epub 2016 May 24.
Acellular (UKRMP1)

High-resolution 3D imaging of osteocytes and computational modelling in mechanobiology: insights on bone development, ageing, health and disease.

Goggin PM, Zygalakis KC, Oreffo ROC, Schneider P.
Eur Cell Mater. 2016 May 22;31:264-95.
Acellular (UKRMP1)

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size

Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, Xie Y, Roma G, Donovan A, Marti P, Beckmann N, Dill MT, Carbone W, Bergling S, Isken A, Mueller M, Kinzel B, Yang Y, Mao X, Nicholson TB, Zamponi R, Capodieci P, Valdez R, Rivera D, Loew A, Ukomadu C, Terracciano LM, Bouwmeester T, Cong F, Heim MH, Forbes SJ, Ruffner H, Tchorz JS.
Nat Cell Biol 2016; 18(5): 467-479.
doi:10.1038/ncb3337
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR Guidelines.

Daley GQ, Hyun I, Apperley JF, Barker RA, Benvenisty N, Bredenoord AL, Breuer CK, Caulfield T, Cedars MI, Frey-Vasconcells J, Heslop HE, Jin Y, Lee RT, McCabe C, Munsie M, Murry CE, Piantadosi S, Rao M, Rooke HM, Sipp D, Studer L, Sugarman J, Takahashi M, Zimmerman M, Kimmelman J.
Stem Cell Reports. 2016 Jun 14;6(6):787-97.
doi:10.1016/j.stemcr.2016.05.001.
Epub 2016 May 12.
Cell behaviour, differentiation and manufacturing (UKRMP1)

Temporally degradable collagen-mimetic hydrogels tuned to chondrogenesis of human mesenchymal stem cells.

Parmar PA, Skaalure SC, Chow LW, St-Pierre JP, Stoichevska V, Peng YY, Werkmeister JA, Ramshaw JA, Stevens MM.
Biomaterials. 2016 Aug;99:56-71. doi: 10.1016/j.biomaterials.2016.05.011. Epub 2016 May 10.
Acellular (UKRMP1)

Mass production of stem cell derived human hepatocytes for experimental medicine

Wang, Y. and D. C. Hay.
Expert Rev Gastroenterol Hepatol 2016; 10(7): 769-771.
doi:10.1080/17474124.2016.1182862
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

Quantitative multi-image analysis for biomedical Raman spectroscopic imaging

Hedegaard MA, Bergholt MS, Stevens MM.
J Biophotonics 2016; 9(5): 542-550.
doi:10.1002/jbio.201500238
Engineering and exploiting the stem cell niche (UKRMP1)

Concise Review: Advances in Generating Hepatocytes from Pluripotent Stem Cells for Translational Medicine

Szkolnicka, D. and D. C. Hay.
Stem Cells 2016; 34(6): 1421-1426.
doi: 10.1002/stem.2368
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs

Szkolnicka D, Lucendo-Villarin B, Moore JK, Simpson KJ, Forbes SJ, Hay DC.
Stem Cells Transl Med 2016; 5(6): 764-772.
doi:10.5966/sctm.2015-0117
Engineering and exploiting the stem cell niche (UKRMP1)

Are Stem Cell-Based Therapies for Parkinson’s Disease Ready for the Clinic in 2016?

Barker, Roger A, Parmar, Malinb, Kirkeby, Agneteb, Björklund, Andersb,Thompson, Lachlanc, Brundin, Patrikd
J Parkinsons Dis. 2016; 6(1):57-63.
doi:10.3233/JPD-160798.
Cell behaviour, differentiation and manufacturing (UKRMP1)
,
Parkinson’s disease

Prospective purification of perivascular presumptive mesenchymal stem cells from human adipose tissue: process optimization and cell population metrics across a large cohort of diverse demographics

West CC, Hardy WR, Murray IR, James AW, Corselli M,, Pang S, Black C, Lobo SE, Sukhija K, Liang P, Lagishetty V, Hay DC, March KL, Ting K, Soo C, Péault B.
Stem Cell Res Ther 2016; 7: 47.
Engineering and exploiting the stem cell niche (UKRMP1)

Fluid shear stress modulation of hepatocyte-like cell function

Rashidi H, Alhaque S, Szkolnicka D, Flint O, Hay DC.
Arch Toxicol 2016; 90(7): 1757-1761.
doi:10.1007/s00204-016-1689-8
Engineering and exploiting the stem cell niche (UKRMP1)

Online monitoring of mechanical properties of three-dimensional tissue engineered constructs for quality assessment

Yvonne Reinwald; Pierre O. Bagnaninchi; Ying Yang; Yanny M. Baba Ismail; Alicia J. El Haj;
Proc. of SPIE 2016; 9710: 971007.
doi:10.1117/12.2212320
Engineering and exploiting the stem cell niche (UKRMP1)

A high-content platform to characterise human induced pluripotent stem cell lines

Leha A, Moens N, Meleckyte R, Culley OJ, Gervasio MK, Kerz M, Reimer A, Cain SA, Streeter I, Folarin A, Stegle O, Kielty CM; HipSci Consortium, Durbin R, Watt FM, Danovi D.
Methods 2016; 96: 85-96.
doi:10.1016/j.ymeth.2015.11.012
Engineering and exploiting the stem cell niche (UKRMP1)

Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies

Heslop JA, Hammond TG, Santeramo I, Tort Piella A, Hopp I, Zhou J, Baty R, Graziano EI, Proto Marco B, Caron A, Sköld P, Andrews PW, Baxter MA, Hay DC, Hamdam J, Sharpe ME, Patel S, Jones DR, Reinhardt J, Danen EH, Ben-David U, Stacey G, Björquist P, Piner J, Mills J, Rowe C, Pellegrini G, Sethu S, Antoine DJ, Cross MJ, Murray P, Williams DP, Kitteringham NR, Goldring CE, Park BK.
Stem Cells Trans Med. 2015; 4 (4) 389-400
doi: 10.5966/sctm.2014-0110.
Epub 2015 Feb 26.

Odontogenic Differentiation of Human Dental Pulp Stem Cells on Hydrogel Scaffolds Derived from Decellularized Bone Extracellular Matrix and Collagen Type I.

Paduano F, Marrelli M, White LJ, Shakesheff KM, Tatullo M.
PLoS One. 2016 Feb 16;11(2):e0148225. doi: 10.1371/journal.pone.0148225. eCollection 2016.
Acellular (UKRMP1)

The effect of injection using narrow-bore needles on mammalian cells: administration and formulation considerations for cell therapies.

Amer MH, Rose FR, White LJ, Shakesheff KM.
Stem Cells Transl Med. 2016 Mar;5(3):366-78. doi: 10.5966/sctm.2015-0208. Epub 2016 Jan 29.
Acellular (UKRMP1)

A Detailed Assessment of Varying Ejection Rate on Delivery Efficiency of Mesenchymal Stem Cells Using Narrow-Bore Needles.

Amer MH, Rose FR, White LJ, Shakesheff KM.
Stem Cells Transl Med. 2016 Mar;5(3):366-78. doi: 10.5966/sctm.2015-0208. Epub 2016 Jan 29.
Acellular (UKRMP1)

Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury.

Arriazu E, Ge X, Leung TM, Magdaleno F, Lopategi A, Lu Y, Kitamura N, Urtasun R, Theise N, Antoine DJ, Nieto N.
Gut. 2016 Jan 27. pii: gutjnl-2015-310752.
doi: 10.1136/gutjnl-2015-310752.
Liver
,
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells.

Reimer A, Vasilevich A, Hulshof F, Viswanathan P, van Blitterswijk CA, de Boer J, Watt FM.
Sci Rep 2016; 6: 18948.
doi: 10.1038/srep18948
Engineering and exploiting the stem cell niche (UKRMP1)

Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration.

Tang D, Tare RS, Yang LY, Williams DF, Ou KL, Oreffo ROC.
Biomaterials. 2016;83:363-82. doi: 10.1016/j.biomaterials.2016.01.024. Epub 2016 Jan 9. Review.PMID: 26803405
Acellular (UKRMP1)

Material cues as potent regulators of epigenetics and stem cell function.

S. Crowder, V. Leonardo, T. Whittaker, M. M. Stevens.
Cell Stem Cell. 2016 Jan 7;18(1):39-52. doi: 10.1016/j.stem.2015.12.012. Review.
Acellular (UKRMP1)

Highly Efficient Delivery of Functional Cargoes by the Synergistic Effect of GAG Binding Motifs and Cell-Penetrating Peptides

Dixon JE, Osman G, Morris GE, Markides H, Rotherham M, Bayoussef Z, El Haj AJ, Denning C, Shakesheff KM.
doi: 10.1073/pnas.1518634113.
Epub 2016 Jan 5.
Cell behaviour, differentiation and manufacturing (UKRMP1)

Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides.

Dixon JE, Osman G, Morris GE, Markides H, Rotherham M, Bayoussef Z, El Haj AJ, Denning C, Shakesheff KM.
Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E291-9. doi: 10.1073/ pnas. 1518634113. Epub 2016 Jan 5.
Acellular (UKRMP1)

2015

Episomal plasmid-based generation of induced pluripotent stem cells from fetal femur-derived human mesenchymal stromal cells.

Megges M, Oreffo RO, Adjaye J.
Stem Cell Res. 2016 Jan;16(1):128-32. doi: 10.1016/j.scr.2015.12.013. Epub 2015 Dec 28.
PMID: 27345797
Acellular (UKRMP1)

Recombinant laminins drive the differentiation and self-organisation of hESC-derived hepatocytes

Dixon JE, Osman G, Morris GE, Markides H, Rotherham M, Bayoussef Z, El Haj AJ, Denning C, Shakesheff KM.
Stem Cell Reports.2015;5(6):1250-62.
doi: 10.1016/j.stemcr.2015.10.016.
Engineering and exploiting the stem cell niche (UKRMP1)

CSF1 Restores Innate Immunity Following Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure

Stutchfield BM, Antoine DJ, Mackinnon AC, Gow DJ, Bain CC, Hawley CA, Hughes MJ, Francis B, Wojtacha D, Man TY, Dear JW, Devey LR, Mowat AM, Pollard JW, Park BK, Jenkins SJ, Simpson KJ, Hume DA, Wigmore SJ, Forbes SJ.
Gastroenterology. 2015;149(7):1896-1909.e14.
doi: 10.1053/j.gastro.2015.08.053.
Engineering and exploiting the stem cell niche (UKRMP1)

Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury

Vliegenthart AD, Shaffer JM, Clarke JI, Peeters LE, Caporali A, Bateman DN, Wood DM, Dargan PI, Craig DG, Moore JK, Thompson AI, Henderson NC, Webb DJ, Sharkey J, Antoine DJ, Park BK, Bailey MA, Lader E, Simpson KJ, Dear JW.
Sci Rep. 2015 Oct 22;5:15501.
doi: 10.1038/srep15501.
Engineering and exploiting the stem cell niche (UKRMP1)
,
Kidney
,
Liver

Overcoming translational challenges – The delivery of mechanical stimuli in vivo.

Markides H, McLaren JS, El Haj AJ.
Int J Biochem Cell Biol. 2015 Dec;69:162-72. doi: 10.1016/j.biocel.2015.10.011. Epub 2015 Oct 19. Review.
Acellular (UKRMP1)

Production of ascorbic acid releasing biomaterials for pelvic floor repair.

Mangır N, Bullock AJ, Roman S, Osman N, Chapple C, MacNeil S.
Acta Biomater. 2016 Jan;29:188-197. doi: 10.1016/j.actbio.2015.10.019. Epub 2015 Oct 19.
PMID: 26478470
Acellular (UKRMP1)

Design considerations for the synthesis of polymer coated iron oxide nanoparticles for stem cell labelling and tracking using MRI

Barrow M, Taylor A, Murray P, Rosseinsky MJ, Adams DJ
Chem. Soc. Rev., 2015,44, 6733-6748
doi: 10.1039/C5CS00331H
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells

Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG.
J. Hepatol. 2015; pii: S0168-8278(15)00340-2.
doi:10.1016/j.jhep.2015.05.013.
Engineering and exploiting the stem cell niche (UKRMP1)

Advanced cell therapies: targeting, tracking and actuation of cells with magnetic particles.

Connell JJ, Patrick PS, Yu Y, Lythgoe MF, Kalber TL.
Regen Med. 2015;10(6):757-72.
doi: 10.2217/rme.15.36.
Epub 2015 Sep 21.
Safety and efficacy, focusing on imaging technologies (UKRMP1)

CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes

Bechler ME, Byrne L, Ffrench-Constant C.
Current Biology. 2015;25(18):2411-2416.
doi:10.1016/j.cub.2015.07.056.
Engineering and exploiting the stem cell niche (UKRMP1)

Autophagic response to cell culture stress in pluripotent stem cells

Gregory S, Swamy S, Hewitt Z, Wood A, Weightman R, Moore H.
Biochem Biophys Res Commun. 2016 May 6;473(3):758-63,
doi:10.1016/j.bbrc.2015.09.080.
Epub 2015 Sep 15.

Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy.

Scarfe L, Rak-Raszewska A, Geraci S, Darssan D, Sharkey J, Huang J, Burton NC, Mason D, Ranjzad P, Kenny S, Gretz N, Lévy R, Kevin Park B, García-Fiñana M, Woolf AS, Murray P, Wilm B.
Sci Rep. 2015 Sep 2;5:13601.
doi: 10.1038/srep13601.
Kidney
,
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting.

Muthana M, Kennerley AJ, Hughes R, Fagnano E, Richardson J, Paul M, Murdoch C, Wright F, Payne C, Lythgoe MF, Farrow N, Dobson J, Conner J, Wild JM, Lewis C.
Nat Commun. 2015 Aug 18;6:8009.
doi: 10.1038/ncomms9009.
Safety and efficacy, focusing on imaging technologies (UKRMP1)

Hepatic progenitor cells of biliary origin with liver repopulation capacity

Lu WY, Bird TG, Boulter L, Tsuchiya A, Cole AM, Hay T, Guest RV, Wojtacha D, Man TY, Mackinnon A, Ridgway RA, Kendall T, Williams MJ, Jamieson T, Raven A, Hay DC, Iredale JP, Clarke AR, Sansom OJ, Forbes SJ.
Nature Cell Biology. 2015;17(8):971-983.
doi:10.1038/nbt.3275.
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

Protocols in In Vitro Hepatocyte Research

Cameron K, Lucendo-Villarin B, Szkolnicka D, Hay DC.
Methods Mol Biol. 2015;1250:v-viii.
PMID: 26491729.
DOI: 10.1007/978-1-4939-2074-7_7
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF)

Rittchen S, Boyd A, Burns A, Park J, Fahmy TM, Metcalfe S, Williams A.
Biomaterials. 2015 Jul; 56:78-85.
Multiple sclerosis

Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance

Baltasar Lucendo Villarin, Kate Cameron, Dagmara Szkolnicka, Hassan Rashidi, Nicola Bates, Susan J. Kimber, Oliver Flint, Stuart J. Forbes, John P. Iredale, Mark Bradley, David C. Hay
Adv. Healthcare Mater. 2015;140:1798-1803.
doi: 10.1002/adhm.201500391.
Engineering and exploiting the stem cell niche (UKRMP1)

Discovery of a new polymer for human pluripotent stem cell expansion and multilineage differentiation

Adam D. Celiz James G. W. Smith Asha K. Patel Andrew L. Hook Divya Rajamohan Vinoj T. George Luke Flatt Minal J. Patel Vidana C. Epa Taranjit Singh Robert Langer Daniel G. Anderson Nicholas D. Allen David C. Hay David A. Winkler David A. Barrett Martyn C. Davies Lorraine E. Young Chris Denning Morgan R. Alexander
Adv. Mater.2015;27(27):4006-4012.
doi:10.1002/adma.201501351
Engineering and exploiting the stem cell niche (UKRMP1)

Stem Cell Heterogeneity and Plasticity in Epithelia

Donati G, Watt FM.
Cell Stem Cell. 2015;16(5):465-476.
doi:10.1016/j.stem.2015.04.014.
Engineering and exploiting the stem cell niche (UKRMP1)

The UKRMP Immunomodulation hub.

Dazzi F, Conroy E.
Regen Med. 2015;10(3):255-7
PMID: 25933234
DOI:10.2217/rme.15.5
Immunomodulation (UKRMP1)

Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9

Lindner M, Thümmler K, Arthur A, Brunner S, Elliott C, McElroy D, Mohan H, Williams A, Edgar JM, Schuh C, Stadelmann C, Barnett SC, Lassmann H, Mücklisch S, Mudaliar M, Schaeren-Wiemers N, Meinl E, Linington C.
Brain 2015;138(Pt 7):1875-93.
doi:10.1093/brain/awv102.
Engineering and exploiting the stem cell niche (UKRMP1)
,
Multiple sclerosis

An automated fabrication strategy to create patterned tubular architectures at cell and tissue scales.

Othman R, E Morris G, Shah DA, Hall S, Hall G, Wells K, Shakesheff KM, Dixon JE.
Biofabrication. 2015 Apr 14;7(2):025003. doi: 10.1088/1758-5090/7/2/025003.
Acellular (UKRMP1)

Applying human cell and regenerative medicine technologies to efficacy and safety testing of new drugs


Workshop hosted by the NC3Rs
UK Regenerative Medicine Platforms Stevenage Bioscience Catalyst NAT SIG and Innovate UK
13 April 2015

Applying human cell and regenerative medicine technologies to efficacy and safety testing of new drugs


Workshop: 13 April 2015
Report published: 17 December 2015

Acellular (UKRMP1)

Collagen-Mimetic Modifiable Hydrogels for Articular Cartilage Regeneration.

P. A. Parmar, L. W. Chow, J. -P. St-Pierre, C. -M. Horejs, Y. Y. Peng, J. A. Werkmeister, J. A. Ramshaw, M. M. Stevens.
Biomaterials. 2015 Jun;54:213-25. doi: 10.1016/j.biomaterials.2015.02.079. Epub 2015 Apr 11.
Acellular (UKRMP1)

Key elements for nourishing the translational research environment.

H. D. Volk, M. M. Stevens, D. J. Mooney, D. W. Grainger, G. N. Duda.
Sci Transl Med. 2015 Apr 8;7(282):282cm2. doi: 10.1126/scitranslmed.aaa2049.
Acellular (UKRMP1)

Cell therapy for liver disease: From liver transplantation to cell factory

Forbes SJ, Gupta S, Dhawan A.
J Hepatol. 2015;62 (1 Suppl): S157-169.
doi:10.1016/j.jhep.2015.02.040.
Engineering and exploiting the stem cell niche (UKRMP1)
,
Liver

The polarity protein scribble regulates myelination and remyelination in the central nervous system.

Jarjour AA, Boyd A, Dow LE, Holloway RK, Goebbels S, Humbert PO, Williams A, ffrench-Constant C.
PLoS Biol. 2015;13(3):e1002107.
doi:10.1371/journal.pbio.1002107.
Engineering and exploiting the stem cell niche (UKRMP1)

High resolution Raman spectroscopy mapping of stem cell micropatterns

von Erlach TC, Hedegaard MA, Stevens MM.
The Analyst. 2015;140(6):1798-803.
doi: 10.1039/c4an02346c.
Engineering and exploiting the stem cell niche (UKRMP1)

Comparative quantification of the surfaceome of human multipotent mesenchymal progenitor cells

Holley RJ, et al.,
Stem Cell Reports.2015;4(3):473-88.
doi:10.1016/j.stemcr.2015.01.007.
Engineering and exploiting the stem cell niche (UKRMP1)

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